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How is it Diagnosed?
The myriad spectrum of leptospirosis makes it difficult to confirm a diagnosis without adequate laboratory facility. Ideally a microbiological confirmation should be sought for, however, it is not always possible, as many laboratories do not have the necessary expertise. In such situations simple clinical, epidemiological and biochemical findings can be of great help in the diagnosis of infection.

After infection, leptospires are present in the blood until they are cleared after 4 to 7 days following the production of anti–Leptospira antibodies, initially mainly of the IgM class. The laboratory diagnosis of leptospirosis mainly relies on the detection of these anti–Leptospira antibodies in patients’ serum. Several methods are available for this purpose: