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Prevention of Leptospirosis How to Prevent Transmission of Leptospirosis? Treatment of Leptospirosis
The antibiotics of choice are penicillin, streptomycin, tetracycline and erythromycin which should be given early in the course of the disease. Intravenous antibiotics may be required for persons with severe symptoms. Persons with symptoms suggestive of leptospirosis should contact a health care provider as soon as possible.

Kidney dialysis may be necessary in some cases. Most cases, even those regarded as severe, tend to complete recuperation despite specific management. General supportive therapy is essential in the management of severe leptospirosis to detect and deal with life–threatening complications (renal failure, hypotension and hemorrhage).

In relation to anti–microbial therapy, there is agreement that either penicillin G or tetracycline may shorten the course of the illness, but only if therapy is started by the fourth day of the illness.

In humans, a number of antibiotics (streptomycin, penicillin and tetracycline) have been administered to treat acute leptospirosis. Penicillin is the drug of choice but other antibiotics are also effective. Tetracycline for penicillin sensitive patients.

A single dose of 25 mg/kg of dihydrostreptomycin has proven to be an effective procedure.

Non specific treatment – analgesics, antipyretics, antihistaminics.

Treatment for complications i.e., dialysis for ARF, mechanical ventilation for acute respiratory distress syndrome (ARDS).

May require Intensive Care Unit (ICU) management.